{"id":5956,"date":"2020-05-09T15:42:25","date_gmt":"2020-05-09T19:42:25","guid":{"rendered":"https:\/\/cendhy.cl\/project\/rho-kinase-cascade-activation-in-circulating-leukocytes-in-patients-with-diabetes-mellitus-type-2\/"},"modified":"2020-05-20T17:38:23","modified_gmt":"2020-05-20T21:38:23","slug":"rho-kinase-cascade-activation-in-circulating-leukocytes-in-patients-with-diabetes-mellitus-type-2","status":"publish","type":"project","link":"https:\/\/cendhy.cl\/en\/project\/rho-kinase-cascade-activation-in-circulating-leukocytes-in-patients-with-diabetes-mellitus-type-2\/","title":{"rendered":"Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.4.5&#8243;][et_pb_row column_structure=&#8221;3_4,1_4&#8243; _builder_version=&#8221;4.4.5&#8243;][et_pb_column type=&#8221;3_4&#8243; _builder_version=&#8221;4.4.5&#8243;][et_pb_text _builder_version=&#8221;4.4.5&#8243; text_font=&#8221;|600|||||||&#8221; text_font_size=&#8221;14px&#8221; text_orientation=&#8221;justified&#8221; hover_enabled=&#8221;0&#8243;]Ocaranza, M.P., Valderas, P., Moya, J. et al. Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2. Cardiovasc Diabetol 19, 56 (2020). https:\/\/doi.org\/10.1186\/s12933-020-01027-2[\/et_pb_text][et_pb_text _builder_version=&#8221;4.4.5&#8243; text_orientation=&#8221;justified&#8221;]The ROCK (unregulated Rho Kinase) intracellular metabolic pathway, which corresponds to the positive regulation of Rho kinase, is an important modulator of blood pressure and cardiovascular and renal remodeling. A role of the ROCK pathway in abnormal glucose metabolism has been described in preclinical animal models of diabetes, however, in humans there is not a large amount of data regarding patients with type 2 diabetes mellitus (T2D) under pharmacological treatment. When compared to healthy subjects, the activation of the ROCK pathway was increased in patients with T2D in treatment with drugs that reduce blood glucose levels, and increased plasma levels of Angiotensin II were also observed. The participating researchers conclude that ROCK inhibition could have an additional role in the prevention and treatment of type 2 diabetes mellitus.[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.4.5&#8243;][et_pb_button button_url=&#8221;https:\/\/cardiab.biomedcentral.com\/articles\/10.1186\/s12933-020-01027-2&#8243; url_new_window=&#8221;on&#8221; button_text=&#8221;VIEW PUBLICATION&#8221; _builder_version=&#8221;4.4.5&#8243; custom_button=&#8221;on&#8221; button_text_size=&#8221;14px&#8221; button_text_color=&#8221;#f5f6f4&#8243; button_bg_color=&#8221;#384b77&#8243; button_border_width=&#8221;0px&#8221; button_border_radius=&#8221;5px&#8221; button_letter_spacing=&#8221;1px&#8221; button_font=&#8221;|600|||||||&#8221; custom_padding=&#8221;|||18px|false|false&#8221; box_shadow_style=&#8221;preset2&#8243; box_shadow_horizontal=&#8221;2px&#8221;][\/et_pb_button][et_pb_button button_url=&#8221;https:\/\/cendhy.cl\/wp-content\/uploads\/2020\/05\/Ocaranza-et-al-.-Cardiovasc-Diabetol-2020.pdf&#8221; url_new_window=&#8221;on&#8221; button_text=&#8221;VIEW PDF&#8221; _builder_version=&#8221;4.4.5&#8243; custom_button=&#8221;on&#8221; button_text_size=&#8221;14px&#8221; button_text_color=&#8221;#f5f6f4&#8243; button_bg_color=&#8221;#384b77&#8243; button_border_width=&#8221;0px&#8221; button_border_radius=&#8221;5px&#8221; button_letter_spacing=&#8221;1px&#8221; button_font=&#8221;|600|||||||&#8221; button_icon=&#8221;%%98%%&#8221; custom_padding=&#8221;|||18px|false|false&#8221; box_shadow_style=&#8221;preset2&#8243; box_shadow_horizontal=&#8221;2px&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_4,1_4,1_4,1_4&#8243; _builder_version=&#8221;4.4.5&#8243;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.4.5&#8243;][et_pb_text _builder_version=&#8221;4.4.5&#8243;]Received<br \/>\n24 January 2020[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.4.5&#8243;][et_pb_text _builder_version=&#8221;4.4.5&#8243;]Accepted<br \/>\n25 April 2020[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.4.5&#8243;][et_pb_text _builder_version=&#8221;4.4.5&#8243;]Published<br \/>\n06 May 2020[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;4.4.5&#8243;][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ocaranza, M.P., Valderas, P., Moya, J. et al. Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2. Cardiovasc Diabetol 19, 56 (2020). https:\/\/doi.org\/10.1186\/s12933-020-01027-2The ROCK (unregulated [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":8394,"comment_status":"open","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"project_category":[33,32],"project_tag":[],"class_list":["post-5956","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-2020-en","project_category-publications"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2 - Cendhy, centro de nuevos f\u00e1rmacos para hipertensi\u00f3n e insuficiencia card\u00edaca<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cendhy.cl\/en\/project\/rho-kinase-cascade-activation-in-circulating-leukocytes-in-patients-with-diabetes-mellitus-type-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2 - Cendhy, centro de nuevos f\u00e1rmacos para hipertensi\u00f3n e insuficiencia card\u00edaca\" \/>\n<meta property=\"og:description\" content=\"Ocaranza, M.P., Valderas, P., Moya, J. et al. Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2. 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